About the Project
Blood development depends on cytokines and their corresponding receptors. Cytokine receptors form dimeric complexes and are coupled to cytosolic tyrosine kinases belonging to the Janus kinase (JAK) family. Binding of the cytokine to its receptor activates signaling via JAK and Signal Transducers and Activators of Transcription (STATs) proteins that shuttle to the nucleus and regulate gene expression. Physiologic cytokine signaling is transient, while mutations that permanently activate signaling of cytokine receptors are oncogenic. The reasons for the latter remain unknown. The PhD project will utilize cell culture and mouse models of JAK2 V617F- and mutant calreticulin- induced blood cancers and especially patient-derived induced pluripotent stem cells, signaling and functional assays to study cytokine receptors and JAK mutants and their impact on organelle function as well as the epigenetic and genetic consequences in normal and pathologic human blood development.
We seek a highly motivated individual holding a Master´s degree or equivalent in a relevant discipline (biomedical sciences, molecular biology, biochemistry, etc). Applications should include a cover letter that outlines the candidate´s motivation, CV and contact information of two references. A good command of English is essential. Experience with bioinformatics analysis is considered an advantage.
To apply, send an email to firstname.lastname@example.org