The group of Dr. Carmen Aguilar at the Institute of Molecular Infection Biology (IMIB)/ Research Center for Infectious Diseases (ZINF) at the Julius-Maximilians-University of Würzburg is offering a

PhD Student/Postdoctoral Researcher position (f/m/d)

“Organoid-based models to explore host pathways controlling uropathogenic Escherichia coli infections”

Applications are invited for a PhD student / postdoctoral researcher position in the Aguilar group at the Institute of Molecular Infection Biology/Research Center for Infectious Diseases in Würzburg. Successful candidates will work in an interdisciplinary project aiming at the development of an organoid-based tissue-engineered model of the human bladder to study host pathways controlling uropathogenic Escherichia coli infection.

Our research group aims to better understand urinary tract infections from the host perspective and to exploit that knowledge to develop new host-directed therapies. We use adult stem cell-derived organoids as models for infection (Aguilar et al. Exp. Mol. Med. 2021) and combine them with a wide range of cutting-edge technologies including advanced microscopy (Confocal, FISH), miRNA profiling, and RNA-seq approaches (i.e. bulk and single cell) as well as numerous molecular biotechnological methods such as gain- and loss-of-function assays (e.g. CRISPR/Cas9 knockout, siRNA, drugs interference; Aguilar et al. Trends in Microbiology 2019, Aguilar et al. Nature Microbiology 2020, Aguilar et al. Nature Communications 2021).

Applicants should have a M.Sc. degree or PhD degree (for postdoctoral fellows) in life sciences and a strong background in either tissue engineering, organoid technology, infection biology, or microbiology. Expertise in molecular biology, RNA-seq data analysis, and bioinformatics is welcome. For informal inquiries, please contact Dr. Carmen Aguilar ([email protected]).

We welcome applications from suitably qualified people from all sections of the community regardless of race, gender, or disability. The University aims to increase the proportion of female employees, therefore applications from qualified women are particularly welcome. Preference will be given to severely handicapped persons in case of otherwise equal aptitude. Positions are initially limited to 1 year with the possibility of extension upon good progress. Salary is based on the pay scale for the public sector in Germany (TV-L).

Please send your application (Subject: PhD/Postdoc position AG Aguilar) including a letter of motivation, CV, publication list, and contact information of two academic references as a single PDF-file until March 31st, 2022 via email to [email protected]

More information about Dr. Aguilar: https://scholar.google.com/citations?hl=en&user=IYJXg-YAAAAJ&view_op=list_works&sortby=pubdate

Institute of Molecular Infection Biology
Department of Molecular Infection Biology II
Josef-Schneider-Str. 2 / Bau D15
97080 Würzburg
Tel. 0931 / 31-88028 (Dr. Carmen Aguilar)

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