Clogged red blood cells, a symptom of sickle cell disease
Blood cells in vessels

All humans have blood but do we all have the same kind of blood? The answer is No. It would amuse you to learn that not all human beings have blood that is red. There are people with green, blue and black colours of blood. Today, we are not going to talk about blood colours. We are diving in to talk about the shape of blood cells, specifically, Sickle Cell Disease.

 In this article, we put put humans in to three groups. People who have all of their blood shaped a full moon (normal), those who have mixture of the normal blood cells and a type that are shaped like a crescent or a half CD disk or crescent (carriers) and finally those who have almost all of their blood shaped like half-moons (Sicklers). The normal red blood cell of a human is shaped like a CD cassette or a full moon, it is perfect for conveying air (oxygen) to all parts of the body. This shape is determined by genes which are transferred from parents to child. Not all humans have the normal red blood cells.

How does someone get sickle cell?

Sickle cell is a heritable disease–meaning it can be transferred from parent to child. The genes that represents sickle cell are Gene A (normal blood cell shape) and Gene S (sickle shaped blood cells). Every human being has a pair of these genes (genotype) but only one of these genes is represented in a sperm cell or egg cell. The normal genotypes are AA (normal), AS (carrier) and SS (sickler).

 A man or a woman with genotype AA can transmit either A or A to a child during fertilization. Similarly, a parent with AS genotype can transmit A or S to their child during fertilization. Also, a person with SS would transmit an S or S to a child during fertilization.

If a woman transmit an A and a man too transmit an A, the child would have the genotype AA (normal) . Similarly, if, one parent transmits an A and the other transmit an S, the child would have the AS genotype (Carriers). Likewise, if a child receive an S from the father and an S from the mother, they would have the sickle cell disorder (SS).

What are the common symptoms of Sickle Cell Disorder?


Normal red blood cells die after 120 days. Sickled red blood cells may die before they reach 20 days. This leads to deficiency in blood cells known as Sickle Cell Anaemia.


Red blood cells around chest region

Sickle cells can congest or jam in blood vessels causing excruciating pain in areas such as the chest, abdomen, bones, etc.

Slow onset of puberty

Healthy red blood cells are essential in delivering nutrients and metabolites to all parts of the body for growth and metabolism. This normal process is obstructed in people with Sickle Cell leading to slow growth and onset of puberty.

Problems with eyesight

Clogging of blood cells in the eye especially around the retina can cause poor processing of images leading to poor eyesight

Frequent infections

The spleen together with other organs are crucial in fighting off pathogenic infections. These organs are sometimes impeded in people with sickle cell, increasing their vulnerability to pathogens.

How long do people with Sickle Cell live?

The current longest living person with sickle cell is more than 94 years old. The recent average life expectancy of people with sickle is 54 years. Often, people with the disease do not understand their bodies well till later in life. Advances in science and increased awareness is expected to have a positive impact on the quality of life of people with the disease.

Whom should I marry with my genotype?

To minimize or prevent giving birth to a child with sickle cell, it is important to check compatibility status with your partner.

Also read: Cancer

Who are AA genotype individuals advised to marry?

AA individuals have no chance of having children with Sickle Cell. In consequence, they can marry any individual with any genotype. To shed more light, they can marry from 100% of the opposite sex so far as sickle cell is concerned.

Who are AS genotype individuals advised to marry?

AS individuals have 25% chance of giving birth to a child with sickle if they marry someone with AS genotype. The percentage increases to 50% if their partner has sickle cell. As a result, it is best for AS individuals to marry partners with AA genotypes.

Who are SS genotype individuals advised to marry?

SS individuals has a 50% chance of having children who are sicklers if they marry AS individuals. The percentage increases to 100% if they marry SS individuals. SS individuals have a 0% chance of having children with sickle cell if their partners are AA. Consequently, SS individuals are strongly advised to marry AA individuals.

Advances in research have significantly improved the quality of life of people with this disease. It is no longer seen as a death sentence. With the right lifestyle and appropriate care, people with sickle cell disease would enjoy quality life like any other person.


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